abexinostat

Term ID

CHEBI:92223

Synonyms

• 3-[(dimethylamino)methyl]-N-[2-[4-(hydroxycarbamoyl)phenoxy]ethyl]-1-benzofuran-2-carboxamide
• 3-[(dimethylamino)methyl]-N-[2-[4-[(hydroxyamino)-oxomethyl]phenoxy]ethyl]-2-benzofurancarboxamide
• 3-[(dimethylamino)methyl]-N-[2-[4-[(hydroxyamino)carbonyl]phenoxy]ethyl]-2-benzofurancarboxamide
• 3-[(dimethylamino)methyl]-N-{2-[4-(hydroxycarbamoyl)phenoxy]ethyl}-1-benzofuran-2-carboxamide
• abexinostat
• abexinostatum
• CRA 024781
• CRA 24781
• CRA-024781
• PCI 24781
• PCI-24781
• PZP-115891
• PZP115891
• S-78454
• S78454

Definition

A 1-benzofuran substituted by {2-[4-(hydroxycarbamoyl)phenoxy]ethyl}aminocarbonyl and (dimethylamino)methyl groups at positions 2 and 3, respectively. It is a potent pan-HDAC inhibitor whose major target is HDAC1 (Ki = 7 nM).

References

• AGR:IND605480874
• CAS:783355-60-2
• DrugBank:DB12565
• HMDB:HMDB0256171
• KEGG:D10060
• LINCS:LSM-2269
• PMCID:PMC4144576
• PMID:16731764
• PMID:18006784
• PMID:18042714
• PMID:19417021
• PMID:19417023
• PMID:20145726
• PMID:20461381
• PMID:21508354
• PMID:22326466
• PMID:23724141
• PMID:23737346
• PMID:23790467
• PMID:23977108
• PMID:24312289
• PMID:25110436
• PMID:25505847
• PMID:25520806
• PMID:25782916
• PMID:26750740
• PMID:27095947
• PMID:27271328
• PMID:28915585
• PMID:32534122
• PMID:33500709
• PMID:34696786
• PMID:38378603
• Wikipedia:Abexinostat

Ontology

ChEBI  ( EBI )