ZFIN ID: ZDB-EXP-240919-5
Experiment Conditions Description: chemical treatment by environment: 2-methyl-6-(phenylethynyl)pyridine
chemical treatment by environment: 2-methyl-6-(phenylethynyl)pyridine
Name: chemical treatment by environment
Synonyms:
Definition: Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water.
Ontology: Zebrafish Environment Condition Ontology [ZECO:0000238]
Name: 2-methyl-6-(phenylethynyl)pyridine
Synonyms: 2-methyl-6-(phenylethynyl)pyridine, 6-Methyl-2-(phenylethynyl)pyridine, MPEP
Definition: A methylpyridine that coinsists of 2-methylp[yridine bearing an additional phenylethynyl group at position 6. Potent and highly selective non-competitive antagonist at the mGlu5 receptor subtype (IC50 = 36 nM) and a positive allosteric modulator at mGlu4 receptors. Centrally active following systemic administration in vivo. Reverses mechanical hyperalgesia in the inflamed rat hind paw.
Ontology: ChEBI [CHEBI:64159]  ( EBI )
Publication: Kozol et al., 2023