| ZFIN ID: ZDB-EXP-240618-1 |
Experiment Conditions Description: surgical manipulation: spinal cord, chemical treatment by environment: bortezomib
| surgical manipulation: spinal cord |
|---|
| Name: | surgical manipulation |
|---|---|
| Synonyms: | |
| Definition: | Experimental condition that involves manual or instrumental techniques to alter anatomical structures. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000176] |
| Name: | spinal cord |
|---|---|
| Synonyms: | medulla spinalis, spinal cord structure |
| Definition: | |
| Ontology: | Anatomy Ontology [ZFA:0000075] |
| chemical treatment by environment: bortezomib |
|---|
| Name: | chemical treatment by environment |
|---|---|
| Synonyms: | |
| Definition: | Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000238] |
| Name: | bortezomib |
|---|---|
| Synonyms: | [(1R)-3-methyl-1-({(2S)-3-phenyl-2-[(pyrazin-2-ylcarbonyl)amino]propanoyl}amino)butyl]boronic acid, bortezomib, N-[(1R)-1-(dihydroxyboranyl)-3-methylbutyl]-N(alpha)-(pyrazin-2-ylcarbonyl)-L-phenylalaninamide, N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE, PS 341, PS-341, Velcade |
| Definition: | L-Phenylalaninamide substituted at the amide nitrogen by a 1-(dihydroxyboranyl)-3-methylbutyl group and at N(alpha) by a pyrazin-2-ylcarbonyl group. It is a dipeptidyl boronic acid that reversibly inhibits the 26S proteasome. |
| Ontology: | ChEBI [CHEBI:52717] ( EBI ) |
| Publication: | Oprişoreanu et al., 2023 |
|---|