Transgenic Construct
Tg(hsp70l:LOXP-Luciferase2-MYC-STOP-LOXP-nYPet-p2A-IkBSR,cryaa:AmCyan)
- ID
- ZDB-TGCONSTRCT-211222-1
- Name
- Tg(hsp70l:LOXP-Luciferase2-MYC-STOP-LOXP-nYPet-p2A-IkBSR,cryaa:AmCyan)
- Previous Names
-
- hsp70l:loxp luc2-myc Stop loxP nYPet-p2a-IkappaBSR, cryaa:AmCyan (1)
- Type
- engineered_plasmid
- Regulatory Regions
- Coding Sequences
- Contains Sequences
- None
- Note
-
This is a heat-shock inducible Cre responder line for inhibition of NF-kappaB signaling. It expresses myc-tagged firefly luciferase 2 prior to recombination and an inhibitor of NF-kappaB signaling, namely a dominant negative mutant mouse IKappa B alpha (IkBSR, IkappaB super-repressor) and nuclear YPet after recombination. AmCyan expression in the lens of the eye serves as transgenesis marker.
Plasmid Map
None
Genomic Features
That Utilize tg(hsp70l:loxp-luciferase2-myc-stop-loxp-nypet-p2a-ikbsr,cryaa:amcyan) Construct
| Genomic Feature | Affected Genomic Regions |
|---|---|
| ulm15Tg |
Transgenics
That Utilize tg(hsp70l:loxp-luciferase2-myc-stop-loxp-nypet-p2a-ikbsr,cryaa:amcyan) Construct
| Fish | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|
| ulm15Tg/ulm15Tg |
|
Fig. 4
from
Sehring et al., 2022
|
Sequence Information
Other Construct Pages
None
Citations