PUBLICATION
Identification of olfactory alarm substances in zebrafish
- Authors
- Masuda, M., Ihara, S., Mori, N., Koide, T., Miyasaka, N., Wakisaka, N., Yoshikawa, K., Watanabe, H., Touhara, K., Yoshihara, Y.
- ID
- ZDB-PUB-240301-11
- Date
- 2024
- Source
- Current biology : CB 34(7): 1377-1389.e7 (Journal)
- Registered Authors
- Miyasaka, Nobuhiko, Yoshihara, Yoshihiro
- Keywords
- Karl von Frisch, Schreckstoff, alarm pheromone, coincidence detection, conspecific signal, danger signal, escape behavior, fish, olfaction
- MeSH Terms
-
- Animals
- Cyprinidae*
- Olfactory Bulb
- Perciformes*
- Smell
- Sulfates
- Zebrafish/physiology
- PubMed
- 38423017 Full text @ Curr. Biol.
Citation
Masuda, M., Ihara, S., Mori, N., Koide, T., Miyasaka, N., Wakisaka, N., Yoshikawa, K., Watanabe, H., Touhara, K., Yoshihara, Y. (2024) Identification of olfactory alarm substances in zebrafish. Current biology : CB. 34(7):1377-1389.e7.
Abstract
Escaping from danger is one of the most ndamental survival behaviors for animals. Most freshwater fishes display olfactory alarm reactions in which an injured fish releases putative alarm substances from the skin to notify its shoaling company about the presence of danger. Here, we identified two small compounds in zebrafish skin extract, designated as ostariopterin and daniol sulfate. Ostariopterin is a pterin derivative commonly produced in many freshwater fishes belonging to the Ostariophysi superorder. Daniol sulfate is a novel sulfated bile alcohol specifically present in the Danio species, including zebrafish. Ostariopterin and daniol sulfate activate distinct glomeruli in the olfactory bulb. Zebrafish display robust alarm reactions, composed of darting, freezing, and bottom dwelling, only when they are concomitantly stimulated with ostariopterin and daniol sulfate. These results demonstrate that the fish alarm reaction is driven through a coincidence detection mechanism of the two compounds along the olfactory neural circuitry.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping