Person

Schartl, Manfred

Person ID: ZDB-PERS-960805-498
Email: phch1@biozentrum.uni-wuerzburg.de
URL: http://www.pch1.biozentrum.uni-wuerzburg.de/
Affiliation: Schartl Lab
Address: Physiologische Chemie I Biozentrum der Universitaet Wuerzburg Am Hubland Wuerzburg, D-97074 Germany
Country: Germany
Phone: 0049-931-31-84148
Fax: 0049-931-31-84150
ORCID ID

Biography and Research Interest

Biography
Diploma/PhD University of Giessen/Germany
Postdoc/Habilitation Ludwig-Maximilian-University, Munich/Germany
Group leader Max-Planck-Institute for Biochemistry, Martinsried/Germany
Full Professor University of Würzburg

Research Interests:
My main research interests are the molecular processes in organismic development and their malfunction in cancerogenesis. One major topic is the understanding of signal transduction and gene regulation in melanoma. We use the classical Xiphophorus model system and transgenic medaka that develop different types of pigment cell tumors. A second major interest is in the molecular basis and evolution of sex determination. Further interests are in the processes that control differentiation and stemness of embryonic stem cells and their relation to cancer stem cells.

Publications

Non-Zebrafish Publications

Teutschbein, J., Haydn, J.M., Samans, B., Krause, M., Eilers, M., Schartl, M. and Meierjohann, S.: Gene expression analysis after receptor tyrosine kinase activation reveals new potential melanoma proteins. BMC Cancer 10 (2010) 386.

Meyer, M.K., Schories, S. and Schartl, M.: Description of Gambusia zarskei sp. n. – a new poeciliid fish from the upper Rio Conchos system, Chihuahua, Mexico (Teleostei: Cyprinodontiformes: Poeciliidae). Vertebrate Zoology 60 (2010) 11-18.

Meierjohann, S., Hufnagel, A., Wende, E., Kleinschmidt, M.A., Wolf, K., Friedl, P., Gaubatz, S. and Schartl, M.: MMP13 mediates cell cycle progression in melanocytes and melanoma cells: in vitro studies of migration and proliferation. Mol Cancer 9 (2010) 201.

Stöck, M., Ustinova, J., Lamatsch, D.K., Schartl, M., Perrin, N. and Moritz, C.: A vertebrate reproductive system involving three ploidy levels: Hybrid origin of triploids in a contact zone of diploid and tetraploid. Evolution 64 (2009) 944-959.

Schories, S., Meyer, M.K. and Schartl, M.: Description of Poecilia (Acanthophacelus) obscura n. sp., (Teleostei: Poeciliidae), a new guppy species from western Trinidad, with remarks on P. wingei and the status of the "Endler's guppy". Zootaxa (2009) 35-50.

Leikam, C., Hufnagel, A., Schartl, M. and Meierjohann, S.: Oncogene activation in melanocytes links reactive oxygen to multinucleated phenotype and senescence. Oncogene 27 (2008) 7070-82.

Hassel, J.C., Winnemoller, D., Schartl, M. and Wellbrock, C.: STAT5 contributes to antiapoptosis in melanoma. Melanoma Res 18 (2008) 378-85.

Maier, S.M., Scherer, S.J., Seifert, M., Hanselmann, R.G., Schleehuber, Y., Edelmann, L., Reichrath, J., Krohne, G., Rescher, U., Seidl, W., Mutschler, W., Claes, L., Welter, C. and Schartl, M.: 1[alpha],25-dihydroxyvitamin D(3) enhances annexin II dependent proliferation of osteoblasts. J Cell Biochem 100 (2007) 679-692.

Wellbrock, C., Weisser, C., Hassel, J.C., Fischer, P., Becker, J., Vetter, C.S., Behrmann, I., Kortylewski, M., Heinrich, P.C. and Schartl, M.: STAT5 contributes to interferon resistance of melanoma cells. Curr Biol 15 (2005) 1629-39.

Wellbrock, C., Weisser, C., Geissinger, E., Troppmair, J. and Schartl, M.: Activation of p59(Fyn) leads to melanocyte dedifferentiation by influencing MKP-1-regulated mitogen-activated protein kinase signaling. J Biol Chem 277 (2002) 6443-54.
96. Stöck, M., Lamatsch, D.K., Steinlein, C., Epplen, J.T., Grosse, W.R., Hock, R., Klapperstück, T., Lampert, K.P., Scheer, U., Schmid, M. and Schartl, M.: A bisexually reproducing all-triploid vertebrate. Nat Genet 30 (2002) 325-8.

Scherer, S.J., Maier, S.M., Seifert, M., Hanselmann, R.G., Zang, K.D., Müller-Hermelink, H.K., Angel, P., Welter, C. and Schartl, M.: p53 and c-Jun functionally synergize in the regulation of the DNA repair gene hMSH2 in response to UV. J Biol Chem 275 (2000) 37469-73.

Nanda, I., Shan, Z., Schartl, M., Burt, D.W., Koehler, M., Nothwang, H., Grutzner, F., Paton, I.R., Windsor, D., Dunn, I., Engel, W., Staeheli, P., Mizuno, S., Haaf, T. and Schmid, M.: 300 million years of conserved synteny between chicken Z and human chromosome 9. Nat Genet 21 (1999) 258-9.

Wittbrodt, J., Shima, A., and Schartl, M. (2002) Medaka--a model organism from the far East. Nat. Rev. Genet.. 3(1):53-64