Person
Joly, Jean-Stephane
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Biography and Research Interest
As part of the TEFOR infrastructure, UMS TEFOR Paris-Saclay CNRS UMS2010 / INRA UMS1451 (UMS TPS) conducts genome editing and phenotyping programs in zebrafish, particularly at larval stages and in the adult brain.
UMS TPS is dedicated to Research and Development of new techniques in the field of genome editing and fluorescence microscopy :
- Genome editing : UMS TPS works with the TACGENE platform on base editing, a targeted and fine edition of the genome.
- Phenotyping : UMS TPS conducts programs to optimize microscopy tools and methodologies, and develops collections of optimal 3D images and navigation tools in these databases.
In order to offer a complete and innovative range of services, UMS TPS coordinates a network of expert centres: a consortium of laboratories and partner platforms experts in fish models whose complementary activities best meet the needs of the scientific community. This way, UMS TPS wishes to help the users in defining the scientific project and relieve them of administrative processes that can be heavy, acting as the main point of contact and support.
Through the creation of the EFOR network (network of functional studies in model organisms), UMS TPS also aims to support and increase the visibility of research projects using model organisms. By developing the accumulated knowledge of the different model organisms and creating spaces for discussion on bioethical issues, EFOR aims to be in line with the 3Rs principles : Reduce, Refine, Replace.
UMS TPS is dedicated to Research and Development of new techniques in the field of genome editing and fluorescence microscopy :
- Genome editing : UMS TPS works with the TACGENE platform on base editing, a targeted and fine edition of the genome.
- Phenotyping : UMS TPS conducts programs to optimize microscopy tools and methodologies, and develops collections of optimal 3D images and navigation tools in these databases.
In order to offer a complete and innovative range of services, UMS TPS coordinates a network of expert centres: a consortium of laboratories and partner platforms experts in fish models whose complementary activities best meet the needs of the scientific community. This way, UMS TPS wishes to help the users in defining the scientific project and relieve them of administrative processes that can be heavy, acting as the main point of contact and support.
Through the creation of the EFOR network (network of functional studies in model organisms), UMS TPS also aims to support and increase the visibility of research projects using model organisms. By developing the accumulated knowledge of the different model organisms and creating spaces for discussion on bioethical issues, EFOR aims to be in line with the 3Rs principles : Reduce, Refine, Replace.
Non-Zebrafish Publications
Brombin A, Grossier JP, Heuzé A, Radev Z, Bourrat F, Joly JS, Jamen F.Genome-wide analysis of the POU genes in medaka, focusing on expression in the optic tectum. Dev Dyn. 2011 Oct;240(10):2354-63. doi: 10.1002/dvdy.22727. Epub 2011 Aug 26. PubMed PMID: 21932313.
Haeussler M, Joly JS. When needles look like hay: how to find tissue-specific enhancers in model organism genomes. Dev Biol. 2011 Feb 15;350(2):239-54.
Tassy O, Dauga D, Daian F, Sobral D, Robin F, Khoueiry P, Salgado D, Fox V, Caillol D, Schiappa R, Laporte B, Rios A, Luxardi G, Kusakabe T, Joly JS, Darras S, Christiaen L, Contensin M, Auger H, Lamy C, Hudson C, Rothbächer U, Gilchrist MJ, Makabe KW, Hotta K, Fujiwara S, Satoh N, Satou Y, Lemaire P. The ANISEED database: digital representation, formalization, and elucidation of a chordate developmental program. Genome Res. 2010 Oct;20(10):1459-68.
Alunni A, Hermel JM, Heuzé A, Bourrat F, Jamen F, Joly JS. Evidence for neural stem cells in the medaka optic tectum proliferation zones. Dev Neurobiol. 2010 Sep;70(10):693-713.
Haeussler M, Jaszczyszyn Y, Christiaen L, Joly JS. A cis-regulatory signature for chordate anterior neuroectodermal genes. PLoS Genet. 2010 Apr15;6(4):e1000912.
Auger H, Sasakura Y, Joly JS, Jeffery WR. Regeneration of oral siphon pigment organs in the ascidian Ciona intestinalis. Dev Biol. 2010 Mar 15;339(2):374-89.
Auger H, Lamy C, Haeussler M, Khoueiry P, Lemaire P, Joly JS. Similar regulatory logic in Ciona intestinalis for two Wnt pathway modulators, ROR and SFRP-1/5. Dev Biol. 2009 May 15;329(2):364-73.
Dahlberg C, Auger H, Dupont S, Sasakura Y, Thorndyke M, Joly JS. Refining the Ciona intestinalis model of central nervous system regeneration. PLoS One. 2009;4(2):e4458.