Person
Roy, Sudipto
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Biography and Research Interest
Our laboratory investigates the cellular and genetic mechanisms that determine pattern during myogenesis and neurogenesis. We use a combination of genetic, molecular and cell biological techniques in the zebrafish and the fruit fly Drosophila to analyse these processes. Much of our current work focuses on the u-boot and iguana mutations that affect distinct steps in the Hedgehog-mediated induction of distinct muscle cells in the somite as well as cell-types in the neural tube of the zebrafish embryo. Our work on Drosophila centres around dissecting the developmental events involved in the specification of the adult muscle fibres of the fly and the segregation of cell fates in the embryonic nervous system.
Non-Zebrafish Publications
(i) DeSimone, S., Coelho, C., Roy, S., VijayRaghavan, K., and White, K. (1996). ERECT WING, the Drosophila member of a family of DNA binding proteins is required in imaginal myoblasts for flight muscle development. Development 120, 31-39.(ii) Roy, S., Shashidhara, L. S., and VijayRaghavan, K. (1997). Muscles in the Drosophila second thoracic segment are patterned independently of autonomous homeotic gene function. Current Biology 7, 222-227.
(iii) Roy, S. and VijayRaghavan, K. (1997). Homeotic genes and the regulation of myoblast migration, fusion, and fibre-specific gene expression during adult myogenesis in Drosophila . Development 124, 3333-3341.
(iv) Roy, S. and VijayRaghavan, K. (1998). Patterning muscles using organisers: Larval muscles and imaginal myoblasts actively interact to pattern the dorsal longitudinal flight muscles of Drosophila. Journal of Cell Biology 141, 1135-1145.
(v) Anant, S., Roy, S., and VijayRaghavan, K. (1998). Twist and Notch negatively regulate adult muscle differentiation in Drosophila. Development 125, 1361-1369.
(vi) Roy, S., and VijayRaghavan, K. (1999). Muscle pattern diversification in Drosophila: The story of imaginal myogenesis. BioEssays 21, 486-498.
(vii) Landgraf, M., Roy, S., Prokop, A., VijayRaghavan, K., and Bate, M. (1999). even skipped determines the dorsal outgrowth of motor axons in Drosophila. Neuron 22, 43-52.
(viii) Roy, S. and Ingham, P. W. (2002). Hedgehogs tryst with the cell cycle. J. Cell Sci. 115, 4393-4397.