ZFIN ID: ZDB-LAB-001113-2 |
Nicolson Lab
|
GENOMIC FEATURES ORIGINATING FROM THIS LAB
Show
all 40 genomic features
STATEMENT OF RESEARCH INTERESTS
Defects in sensory hair cells are thought to account for most forms of hereditary deafness. We aim to identify the components involved in hair-cell function by using a genetic approach. By screening over 7000 genomes (Tuebingen Screens I & II), we have identified a total of 24 genes that are required for balance and hearing in zebrafish. These circler mutants are analogous to the mouse shaker-waltzer mutants and can serve as alternative models for the study of human deafness. We are currently developing new ways of analyzing our mutants such stably expressing hair-cell specific markers, creating behavioral tests for auditory and vestibular function, and measuring physiological responses in hair cells and acousticolateralis nerves.
LAB MEMBERS
Gao, Yan Post-Doc | Shipman, Anna Post-Doc | Sun, Peng Post-Doc |
Brodo-Abo, Sivan Research Staff |
ZEBRAFISH PUBLICATIONS OF LAB MEMBERS