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Figure 5

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ZDB-IMAGE-230211-35
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Figures for Quint et al., 2023
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Figure 5

Mutants with increased axial length show a myopic shift in refractive status. Refractive status measured by eccentric photorefraction. The lama2, lrrc4c, kcnq5 mutants showed a myopic shift in refractive status at 2mpf (lama2 mutant: effect size = − 1.4D, p = 0.018; lrrc4c mutant: effect size = − 3.4D, p < 0.0001; kcnq5 mutant: effect size = − 2.4D, p = 0.003) and 4mpf (lama2 mutant: effect size = − 2.0D, p < 0.0001; lrrc4c mutant: effect size = − 1.2D, p = 0.003; kcnq5 mutant : effect size = − 2.6D, p < 0.0001), relative to WT (n = 20 eyes per timepoint). The tjp2 mutant showed a hyperopic shift at 4mpf (effect size = + 2.1D, p = 0.001). See Supplementary Data S5 for all data. Error bars: SEM. Significance: ns = not significant, *p < 0.05, **p < 0.01, ***p < 0.001. Mpf: months post-fertilization, WT: wild-type, tjp2 mutant: tjp2ab1367tjp2bb1368, pde11a mutant: pde11are13pde11a-likere14, shisa6 mutant: shisa6re15, lama2 mutant: lama2re16, lrrc4c mutant: lrrc4care17lrrc4cbre18, kcnq5 mutant: kcnq5are19kcnq5bre20, SEM: Standard error of the mean.

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