ZFIN Image: Friedrich et al., 2012, Fig. 5

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Figure Caption

Fig. 5

The free amino acid profile of que mutants shows elevated levels of BCAAs at 96 hpf. The amino acids are referred to by their three-letter code, except for GABA. Each experiment contained a homogenate of 50 larvae. The error bars indicate standard error. (A) The free amino acid profile for wild-type larvae (n=3). (B) The free amino acid profile of que mutant larvae reveals a dramatic accumulation of BCAAs: isoleucine, leucine and valine. Other amino acid levels were reduced. * Significant difference from wild-type at P<0.05; ** significant difference from wild-type at P<0.01 (n=3). (C) The free amino acid profile of beo, a zebrafish mutant that demonstrates abnormal behavior owing to a CNS defect, indicates that abnormal behavior alone does not markedly alter free amino acid levels (n=1).

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Acknowledgments

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