ZFIN Image: Ramel et al., 2005, Fig. 6

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Figure Caption

Fig. 6 Vent and Vox function redundantly to repress myoD expression. A–H: In situ hybridization for myoD at bud stage. Dorsal views, anterior is up. Insets show dorso-vegetal views, dorsal up. Injected morpholinos are indicated above each panel, all morpholinos were injected at 5 ng/nL each. The percentage of treated embryos displaying the phenotype shown in each panel is indicated. Horizontal bars indicate width of adaxial myoD⁺ domain. Vent and Vox double knockdown recapitulates the Df^st7 phenotype (B), while knockdown of Vent or Vox individually results in a mild phenotype (C, D). ved-MO-injected embryos display a wild-type myoD pattern (E). Double morphant combinations (B, F, G, H) show that the loss of Vox + Vent or Vox + Ved gives rise to a ventrally expanded myoD (arrow in insets).

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Acknowledgments

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Reprinted from Developmental Biology, 287(2), Ramel, M.C., Buckles, G.R., Baker, K.D., and Lekven, A.C., WNT8 and BMP2B co-regulate non-axial mesoderm patterning during zebrafish gastrulation, 237-248, Copyright (2005) with permission from Elsevier. Full text @ Dev. Biol.