Gene

tars2

ID
ZDB-GENE-070815-3
Name
threonyl-tRNA synthetase 2, mitochondrial
Symbol
tars2 Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 16 Mapping Details/Browsers
Description
Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 21. Orthologous to human TARS2 (threonyl-tRNA synthetase 2, mitochondrial).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Accogli et al., 2023
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Accogli et al., 2023
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With tars2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
combined oxidative phosphorylation deficiency 21 Alliance Combined oxidative phosphorylation deficiency 21 615918
Associated With tars2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR002314 Aminoacyl-tRNA synthetase, class II (G/ P/ S/T)
Domain IPR004095 TGS
Domain IPR004154 Anticodon-binding
Domain IPR006195 Aminoacyl-tRNA synthetase, class II
Domain IPR033728 Threonine-tRNA ligase catalytic core domain
Domain IPR047246 Threonine-tRNA ligase, class IIa, anticodon-binding domain
Family IPR002320 Threonine-tRNA ligase, class IIa
Homologous_superfamily IPR012675 Beta-grasp domain superfamily
Homologous_superfamily IPR018163 Threonyl/alanyl tRNA synthetase, class II-like, putative editing domain superfamily
Homologous_superfamily IPR036621 Anticodon-binding domain superfamily
Homologous_superfamily IPR045864 Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL)
Domain Details Per Protein
Protein Length Aminoacyl-tRNA synthetase, class II Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) Anticodon-binding Anticodon-binding domain superfamily Beta-grasp domain superfamily Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL) TGS Threonine-tRNA ligase catalytic core domain Threonine-tRNA ligase, class IIa Threonine-tRNA ligase, class IIa, anticodon-binding domain Threonyl/alanyl tRNA synthetase, class II-like, putative editing domain superfamily
UniProtKB:A0A8M9PJQ9 687
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Citations