Gene
prrx1b
- ID
- ZDB-GENE-030131-9033
- Name
- paired related homeobox 1b
- Symbol
- prrx1b Nomenclature History
- Previous Names
-
- phox1 (1)
- fa97b09
- wu:fa97b09
- zgc:64199
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to have sequence-specific DNA binding activity. Involved in cranial skeletal system development and positive regulation of gene expression. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in agnathia-otocephaly complex. Is expressed in several structures, including mesenchyme; pectoral fin bud; pectoral fin field; pharyngeal arch; and pleuroperitoneal region. Orthologous to human PRRX1 (paired related homeobox 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from de Bakker et al., 2021
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| agnathia-otocephaly complex | Alliance | Agnathia-otocephaly complex | 202650 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Homedomain-like superfamily | Homeobox, conserved site | Homeodomain | OAR domain | Paired mesoderm homeobox protein 1/2 |
|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M2B7I0
|
240 | |||||
|
UniProtKB:Q6P295
|
245 | |||||
|
UniProtKB:A0A8M6YUR5
|
267 |
| Type | Name | Annotation Method | Length (nt) | Analysis |
|---|---|---|---|---|
| mRNA |
prrx1b-201
(1)
|
Havana | 2766 nt | |
| mRNA |
prrx1b-202
(1)
|
Havana | 943 nt |
Interactions and Pathways
No data available
Plasmids