FIGURE

Figure 1

ID

ZDB-FIG-200807-15

Publication

Meshalkina et al., 2020 - SpCas9- and LbCas12a-Mediated DNA Editing Produce Different Gene Knockout Outcomes in Zebrafish Embryos

Other Figures

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Figure 1

The mechanisms of action of LbCas12a (a) and SpCas9 (b) nucleases. LbCas12a cleaves far from PAM and SpCas9 cleaves near PAM, in the seed region. TTTN -represents the PAM sequence for LbCas12a, NGG is the PAM sequence for SpCas9, cleavage sites by nuclease domains (RuvC and HNH) are labeled with red triangles (pink triangle labels an alternative cut site, producing staggered ends).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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